Detection and analysis of genetic polymorphisms
Support for selecting beef breed animals
Characterization, trials, testing
Advice, expertise, training
Research and development
Fields of application
Bovine genomics, Agronomy, Health Agriculture, Agri-food
Tools for DNA, RNA and protein analysis
Tools for cell assays
Competitiveness Clusters with which
the laboratory is associated :
(at 1st January 2012)
Teacher-researchers : 15
EPST and EPIC researchers : 2
Other researchers : 1
HDR (accredited to direct research) : 6
Doctoral students (2011-2012) : 10
Engineers, technicians : 6
Administrative agents : 1
Dissertations defended (2008-2011) : 12
Current national projects : 2 INRA
Current European projects : 1 Franco-Hungarian project
Other projects : 2 international cooperation projects
(2008 - 2011)
Number of patents filed : 2 with the INRA
Industrial or research agreements with major organizations : 10
Start-up created as a result of research activities since 2005 : Glycode
National conferences, seminars organized : 2
The scientific aim of the UMR1061 (Joint Research Team) is to contribute to the improvement of knowledge of the bovine genome, in particular to better understand how genetic variability controls the phenotypic variability of some traits of agronomic interest.
Our projects focus on genes that are likely to regulate the early stages of muscle differentiation and muscle development as well as genes that may control sensory properties of meat. We are involved in genome screening based on high-throughput genotyping and on transcriptomic and proteomic analysis, with the dual aim to identify (i) regions of the genome and target genes for further functional genomics analysis, and (ii) genetic markers that can be used for selection.
We use integrative biology, genetics, epigenetics and functional genomics methods. We work with animal models in order to address fundamental scientific issues and we validate concepts in application models (livestock animals), in particular in bovines.
These scientific objectives lean on 3 complementary
theme-based groups :
(i) Glycosylation and Myogenesis,
(ii) Muscle Development and Animal Models,
(iii) Functional Analysis of genes involved in traits of interest in cattle.
Active National University Partnerships :
University of Lille, Blaise Pascal University-Clermont-Ferrand, University of Auvergne Clermont-Ferrand, Pasteur Institute Paris, INSERM U602, University of Paris 11-South, University of Montpellier
Current International University Partnerships :
University of Pisa (Italy)
University of Bologna (Italy)
Lebanese University (Lebanon)
Debrecen University (Hungary)
Pécs University (Hungary)
Blida University (Algeria)
National Industrial Partnerships :
Institute of Animal Husbandry, UNCEIA (National Association of Livestock and Artificial Insemination Cooperatives), Ingenomix, Lanaud Centre, Melipharm
Partnerships with National Organizations and Institutions :
Scientific interest groups (GIS) :
Viandes et Produits Carnés (Innoviandes) Competitiveness Cluster
CELEGEN (Limousin Centre for Exploitation of the Bovine Genome)
AGENAE (Genomics Analysis of Livestock)
Research Federation :
Website publication : hal-unilim.archives-ouvertes.fr
Articles : 79 in peer-reviewed journals
Number of works : 5
Conference presentations : 240
Major publications and/or patents over the last 5 years
• Janot M., Audfray A., Loriol C., Germot A., Maftah A. and Dupuy F.
(2009) “Glycogenome expression dynamics during mouse C2C12 myoblast
differentiation suggests a sequential reorganization of membrane
glycoconjugates”. BMC Genomics, 10 : 483.
• Laporte, B., Gonzalez-Hilarion, S., Maftah, A., Petit, J.M. (2009) “The second bovine - Galactoside 2.6 sialyltransferase (ST6Gal II) : genomic organization and stimulation of its in vitro expression by IL-6 in bovine mammary gland epithelial cells”. Glycobiology 19, 1082–1093.
• Williams J.L., Dunner S. ; Valentini A., Mazza R., Amarger V., Checa M.L., Crisà A., Razzaq D. Delourme D., Grandjean F., Marchitelli C., Garcia D., Pérez Gomez R., Negrini R., Ajmone-Marsan, P. and Levéziel H. 2009. “Discovery, characterization and validation of single nucleotide polymorphisms within 206 bovine genes that may be considered as candidate genes for beef production and quality”. Animal Genetics, 40, 486-491.
• Martin R, Chantepie S, Chapuis J, Le-Duc A, Maftah A, Papy-Garcia D, Laude H, Petit JM, Gallet PF. 2011. “Variation in Chst8 gene expression level affects PrP(C) to PrP(Sc) conversion efficiency in prion-infected Mov cells”. Biochem Biophys Res Commun. 2011 Oct 1. [Epub ahead of print]
• L. Magnol, O. Monestier, K. Vuillier-Devillers, S. Wagner, O. Cocquempot, M. C. Chevallier and V. Blanquet. (2011). “A sensitised mutagenesis screen in the mouse to explore the bovine genome : study of muscle characteristics”. Animal, 5 : 663-671.
• X. Blanchet, A. Péré-Brissaud, N. Duprat, E. Pinault, D. Delourme, A. Ouali, C. Combet, A. Maftah, P. Pélissier and L. Brémaud. (2012). “Mutagenesis of the bovSERPINA3-3 demonstrates the requirement of aspartate-371 for intermolecular interaction and formation of dimmers”. Protein Science, 21 (7) : 277- 286.
• R. Ciampolini, F. Cecchi, A. Spaterna, A. Bramante, S. M. Bardet and A. Oulmouden. (2012). “Characterization of different 5′-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs”. Animal genetics, April 24th
• Brun C, Monestier O, Legardinier S, Maftah A, Blanquet V. “Murine GASP-1 N-Glycosylation is not Essential for its Activity on C2C12 Myogenic Cells but Alters its Secretion”. Cell Physiol Biochem. 2012 ; 30(3) : 791-804. • Laporte B, Petit DP, Rocha D, Boussaha M, Grohs C, Maftah A, Petit JM. “Characterization of bovine FUT7 furthers understanding of FUT7 evolution in mammals”. BMC Genet. 2012 Aug 21 ; 13(1):74.
• Monestier O, Brun C, Cocquempot O, Petit D, Blanquet V. “GASP/WFIKKN Proteins : Evolutionary Aspects of Their Functions”. PLoS One. 2012 ; 7(8):e43710. Epub 2012 Aug 24.
Faculté des Sciences
123 AV Albert Thomas
87060 LIMOGES Cedex
Tel : +33 (0)5 55 45 76 77
Fax +33 (0)5 55 45 76 84
Genomics, Environment, Immunity, Health and Therapeutics (FR 3503 GEIST)
ED 524 Biology, Health « Biohealth »
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